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</a> Women randomized to estrogen and progestin had significantly elevated risks for coronary heart disease breast cancer stroke pulmonary embolism dementia (in women 65 years of age and older) gallbladder disease and urinary incontinence. On the other hand they were at reduced risk for hip fractures diabetes and vasomotor symptoms. After discontinuation of therapy most of the effects both positive and negative were no longer apparent though a small increase in breast cancer risk remained.
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